Lysozyme is a well-known antimicrobial, globular protein found to be piezo, pyro and ferroelectric in its crystalline state. Here, we have fabricated a piezoelectric energy harvesting device using engineered te-tragonal aggregate films of lysozyme. Deposited films exhibited both longitudinal and shear piezoelectric-ity between 3-13 pC/N. Subsequent output voltage/current of the device have been recorded. Considering the non-toxicity and biocompatibility, this approach offers a big advantage over inorganic/synthetic piezoelectric materials as self-powered biomedical sensor, implantable power source in body, and antimicro-bial coating in medical implants.